How do the measurements understand genes?
Most people understand that a high waist circumference means that you are at a higher risk of heart disease and diabetes. It is now known that measures like a bigger wrist and neck circumferences give an indication of diabetes risk as well – even if there is a small waist circumference! Relationships like this exist throughout the body, and the relate to skeletal structure. In fact, after 20 000 case studies and in-depth analysis of the human form, the ph360 scientific team we are to identify 80 different measures and ratios that relate to a person’s genetic make-up. Anthropometry is the first layer of ph360. The following 14 layers of ph360 include endocrinology, embryology, neurophysiology, epigenetics, phenotypology, semeiotics, traditional medicine principles, exposomics, geomedicine and others that help to understand the whole environment around the individual. As a persons information is collected and filtered through each layer, 10,000 relationships through 500 individual algorithms are used to create a profile as unique as the individual taking the assessment – even identical twins have different requirements. (Go to the end of the page if you are wanting even more information on the measures and their relationships)
How does it differ from standard DNA testing?
Typically when you measure your DNA through saliva or blood, you get a read out of exactly the type of gene you have – i.e. Blond hair or brown hair, or genes that put you at risk for diabetes etc. However, while you may have a gene that codes for brown hair, you might currently have gray hair…where did the brown hair gene go? The simple answer is that you have the same DNA and genes your whole life, however, when the environment changes, or when you age, those same genes behave differently. What was an active brown hair gene is now inactive, and other genes that were inactive are now actively making gray hairs. To use the diabetes example, you may have genes that put you at risk of poor blood sugar control, however you may be exercising regularly, eating great foods and providing a stress free environment, and so those genes don’t activate. However, you change the environment to poor food, no exercise and lots of stress, these diabetes genes activate and start disrupting your blood sugar control. You had the same genes the whole time, however the environment changed. Ph360 is able to determine not only the genes and DNA you have, but it also understands which genes are ‘ON’ and which are ‘OFF’. From here, it provides guidance based on your current genetic expression, so you have advice that matches you right now, and as you change, so will the advice. You at one year old and 70 years old will need different advice, although you have exactly the same DNA the whole time – it all depends on what genes are active at any point in time
Can you tell me more about the science please?
The genetic information held within our DNA can be seen in our physiology in some form or another. Genes code for the size and thickness of our bones, how much and where we hold fat & muscle tissue, the colour of our eyes, hair, skin, the way we physically develop as children, the diseases of which we are at greater risk, and many others. When these and other factors are assessed through specific combinations of correlations, the gene variants within an individual can be calculated. This method has been complex to establish and requires advanced technology to process and integrate, however, an international team working for 2 decades on research and software development have informed the basis for what are now trusted methods of determining phenotype and the resulting individual requirements.
Both the measures and the questionnaire used as part of the assessment in ph360 have been mapped to the genome using existing data from an international consortium focussing on genetic research. The combination of genetic mapping and quantifying phenotype gives information on neural activity correlated to EEG measures, hormonal dominance, nutrigenomic requirements and chronobiological and biomechanical considerations. This information is used to inform a more comprehensive picture of both disease risk, current health state, and recommended actions for improvement of condition.
This calculations performed are constantly updated and revised using new findings as they come to light to adjust and add quantifiable metrics and therapeutic recommendations.